PDEIII Meaning and
Definition
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PDEIII, or Phosphodiesterase III, is an enzyme that is part of the phosphodiesterase family. It plays a crucial role in regulating the levels of cyclic adenosine monophosphate (cAMP) within cells. PDEIII specifically targets cAMP and catalyzes its breakdown into inactive products. This enzymatic activity ultimately leads to the termination of downstream signaling pathways that rely on cAMP as a signaling molecule.
The presence of PDEIII in various tissues and cells makes it an important regulator of numerous physiological processes. In cardiac and smooth muscle cells, PDEIII acts to decrease cAMP levels, resulting in the relaxation of smooth muscle fibers and a reduction in cardiac contractility. This effect is attributed to the enzyme's inhibitory action on protein kinase A, an essential mediator of cAMP-dependent cellular responses.
Due to its role in modulating cAMP levels, PDEIII has garnered significant attention in pharmacology. Various drugs and compounds have been developed to selectively inhibit PDEIII activity, resulting in an increase in cAMP levels within cells. These inhibitors have been explored as potential therapeutics to target conditions characterized by reduced cardiac contractility or abnormalities in smooth muscle tone. PDEIII inhibitors have also been investigated for their potential to treat other disorders, such as asthma, due to their impact on smooth muscle relaxation.
In summary, PDEIII is an essential enzyme that regulates cAMP levels within cells. Its inhibitory action on cAMP-dependent signaling pathways makes it an attractive target for pharmacological interventions.
Common Misspellings for PDEIII
- odeiii
- ldeiii
- -deiii
- 0deiii
- pseiii
- pxeiii
- pceiii
- pfeiii
- preiii
- peeiii
- pdwiii
- pdsiii
- pddiii
- pdriii
- pd4iii
- pd3iii
- pdeuii
- pdejii
- pdekii
- pdeoii
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